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The major active metabolite is the sulfoxide, which may be converted back to ethionamide in vivo. Chemistry and Stability Chemistry Ethionamide is a synthetic, isonicotinic acid-derivative antituberculosis agent.
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Missed dose If you missed a dose take it as soon as you remember, if it is almost time of your next dose just skip it and return to your dosing schedule. Never double dose this medication. Overdose Symptoms of overdose for this medication are unknown. Practically insoluble in water; sparingly soluble in alcohol; soluble in methyl alcohol.
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The United States Pharmacopeia 31, 2008 Ethionamide. generic Aggrenox bright yellow powder having a faint to moderate sulfide-like odour. Slightly soluble in water, in chloroform, and in ether; sparingly soluble in Trecator Sc pill Without Prescription Online and in propyleneglycol; soluble in methyl alcohol, Trecator Sc Pills Without Prescription Online. Store in airtight containers. Uses Active Tuberculosis Ethionamide is used in conjunction with other antituberculosis agents in the treatment of clinical tuberculosis.
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If an alternative agent is needed for these regimens in patients who will not accept or cannot tolerate clofazimine or in patients who cannot receive rifampin because of adverse effects, intercurrent disease e. Dosage Active Tuberculosis In the treatment of clinical tuberculosis, ethionamide should not be given alone. Therapy for tuberculosis should be continued long enough to prevent relapse. The minimum duration of treatment currently recommended for patients with culture-positive pulmonary tuberculosis is 6 months 26 weeks, and recommended regimens consist of an initial intensive phase 2 months and a continuation phase usually either 4 or 7 months.
However, completion of treatment is determined more accurately by the total number of doses and is not based solely on the duration of therapy. The manufacturer states that initiation of therapy with a dosage of 250 mg daily, with gradual titration to optimal dosage as tolerated by the patient, also may be beneficial.
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Other Adverse Effects Hypersensitivity reactions including rash, photosensitivity, thrombocytopenia, and purpura have been reported rarely with ethionamide. Goiter, with and without hypothyroidism, has also been associated rarely with ethionamide therapy. Hypoglycemia, gynecomastia, impotence, menorrhagia, joint pain, acute rheumatic symptoms, and acne have also occurred.